Jacksonville Jaguars head coach Doug Pederson said that running back Tank Bigsby (ankle) will practice on Friday for the first time this week. "Optimistic... today will be a big day for him," Pederson said.

According to NFL Network’s Tom Pelissero, the Jaguars have officially ruled out RB Tank Bigsby and QB Trevor Lawrence for Week 11. Lawrence will miss his second-straight game with a shoulder injury while Bigsby will miss his first game this season with an ankle injury.

Jacksonville Jaguars running back Tank Bigsby is listed as questionable for Week 9 against the Philadelphia Eagles, but he is expected to play through his ankle

Analysis: Star Lions tight end Sam LaPorta was ruled out against the Jaguars after missing each day of practice this week with a shoulder injury. Backup linebacker Ben Niemann joined the injury report Friday with an ankle injury. Read all the best Jags coverage at Jacksonville.com and Jags Wire.

In the NFL, every game is a new story, and the Jacksonville Jaguars’ saga is no exception. With a mixed season that includes injuries, disappointments, and new opportunities, the Jaguars are bracing for another shake-up.

The Jacksonville Jaguars' task on Sunday against the Detroit Lion got harder. The 2-8 team in last place in the AFC South will face the NFC North leaders without quarterback Trevor Lawrence. Lawrence has been nursing a left shoulder injury.

Today's episode focuses on the news of the Jacksonville Jaguars being set to miss Trevor Lawrence in Week 11 vs. the Detroit Lions.

Lawrence’s long-term health is an obvious priority for the franchise, given his five-year, $275M extension signed this offseason.