Italy’s highest court on Thursday confirmed a slander conviction against U.S. defendant Amanda Knox for accusing an innocent man of murdering her British flatmate 17 years ago in a sensational case that polarized trial watchers on both sides of the Atlantic.

An American who was convicted and later acquitted of the 2007 murder of her British housemate, Ms. Knox was found guilty of falsely accusing someone else of the crime.

Knox was appealing a 2024 conviction for falsely accusing her former boss of murdering her roommate, an assertion she made under aggressive police questioning.