Recent evidence suggests methylene blue may help reduce vasopressor needs and ICU stays in septic shock, but current data do ...

About Evoke Pharma, Inc. Evoke is a specialty pharmaceutical company focused primarily on the development of drugs to treat ...

Evoke Pharma, Inc. (NASDAQ: EVOK), a specialty pharmaceutical company focused primarily on treatments for gastrointestinal (GI) diseases with an ...

Solid Biosciences Announces FDA IND and Health Canada CTA Approval for First-in-Class Cardiac Gene Therapy to Treat Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) ...

The pathophysiology can be broadly divided in 2 phases. The first phase starts with cognitive centers of the brain with a special role of the hypothalamic–pituitary–adrenal axis resulting in ...

Taken together with markedly elevated catecholamine levels, these findings supported the diagnosis of catecholamine-induced Takotsubo cardiomyopathy. This patient’s course was further complicated by ...

Solid Biosciences Announces FDA IND and Health Canada CTA Approval for First-in-Class Cardiac Gene Therapy to Treat Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) ...

Parkinsonian diseases comprise a heterogeneous group of neurodegenerative disorders, which show significant clinical and pathological overlap. Accurate diagnosis still largely relies on clinical ...

Neurotransmitters and neuromodulators mediate communication between neurons and other cell types; knowledge of release dynamics is critical to understanding their physiological role in normal and ...

All animal experiments for evaluating drug efficacy or developing medical devices are unavoidably accompanied by bleeding that result in unreliable outcomes with large variations between individuals.

Reduction of catecholamine synthesis by as much as 70% has been achieved in man with the oral administration of a-methyl-para-Ltyrosine, a tyrosine hydroxylase inhibitor. Significant reduction of ...

The pathophysiology of heart failure is complex, but mitochondrial dysfunction is an emerging therapeutic target to improve cardiac function. In this Consensus Statement, insights into the ...