Value of Serum Human Epidermal Growth Factor Receptor 2 (HER2)/ neu Testing for Early Prediction of Response to HER2/ neu -Directed Therapies Is Still an Open One and Deserves Further Study in Large ...

The German Institute for Quality and Efficiency in Health Care (IQWiG) has examined the pros and cons of biomarker-based ...

HER2/neu shows both ligand-independent and ligand-dependent activity, and investigation of each of these activities has provided valuable information regarding the mechanisms of transformation ...

Anti-HER2/neu therapy is well-established in breast and gastric carcinoma. The increased understanding of this pathway led to the identification of new promising drugs in addition to trastuzumab ...

The FISH (fluorescence in situ hybridization) test checks the DNA of your cancer cells for extra copies of the HER2/neu gene.

Medically reviewed by Lindsay Cook, PharmD If you have HER2-positive breast cancer, your options for treatment will depend on several factors, such as the stage of cancer (early or metastatic) and ...

Researchers then implanted a HER2/neu-positive tumor into mammary tissue in the mice. All of the control mice developed breast cancer but only one mouse in each of the VRP-neu groups did.

Based on successful animal studies, a novel vaccine that uses immune cells as factories to produce Her2/neu protein may offer a way to treat some human breast cancers, say researchers at The ...

Find out all you need to know about Herceptin (trastuzumab) for early and more advanced HER2-positive breast cancer, including what to expect, outcomes, side effects, and more.

HER2/ neu is a source of immunologic peptides and approximately 30% of early-stage breast cancers have an amplified HER2/ neu gene or overexpression of its protein product.

We know that HER2-positive breast cancer has the potential to behave more aggressively, and it has a higher risk of returning post-treatment. Historically, that was something that we could only lament ...

We hypothesized that immunizing patients with subdominant peptide epitopes derived from HER-2/neu, using an adjuvant known to recruit professional antigen-presenting cells, granulocyte-macrophage ...