Calcium is one of the most abundant and important minerals in the body, playing a crucial role in how we function. Not getting enough can put you at risk for weakened bones that may progress to ...

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

Abstract: We expressed the importance of frequency characteristics of T-type calcium signaling in every level of the nervous system. We also highlighted the need for performing frequency analysis on ...

Transgenic tobacco leaves after 24 hours of green light exposure: a, plant with anion channel GtACR1; green light-induced membrane potential change (depolarization) is shown on the left. b, plant with ...

Bone loss is a natural part of getting older, but prioritizing certain foods can help slow the process down. By Nikki Campo As we age, our bodies break down more bone tissue than they build. This can ...

Calcium is critical for bone health, optimal muscle activity, and other body processes such as blood clotting and heart function. How much calcium you need depends on your age and stage of life. Share ...

A tamoxifen-inducible, nodal tissue-specific, knockdown mouse of Jph2 was achieved using a Cre-recombinase-triggered short RNA hairpin directed against Jph2 (Hcn4:shJph2). In vivo cardiac rhythm was ...

I am interested in how cells communicate and process information through the use of systems of interacting signaling molecules, especially ion channels, and transporters. Behind this interest is a ...

Decision letter after peer review: Thank you for submitting your article "Live Imaging Reveals the Cellular Events Downstream of SARM1 Activation" for consideration by eLife. Your article has been ...

Contacts between the endoplasmic reticulum (ER) and plasma membrane (PM) contain specialized tethering proteins that bind both ER and PM membranes. In excitable cells, ER–PM contacts play an important ...