Before the 49ers and Cardinals face off in their NFC West battle, check out these bold predictions. Can Arizona pull off the upset?

Dabo Swinney and the Clemson Tigers look to avoid a second straight loss to Jeff Brohm and Louisville. Here's ESPN SP+'s score prediction for Friday.

With a couple of huge assists from Tyrice Knight, Lawrence doubled his career total by the end of a dominant first half for the Seattle Seahawks, who beat the Arizona Cardinals 44-22. Lawrence returned two fumbles for touchdowns, and became the sixth player since at least 1991 with two defensive touchdowns in the first half of a game.

The Cardinals are not worried about rookie defensive linemen Walter Nolen III's leg injury suffered in Week 10 loss to Seahawks

See who's in and who's out for the Week 10 matchup between the Los Angeles Rams and San Francisco 49ers on November 9, 2025.