As President Donald Trump rolls out his “America First” policies, few countries have more to lose than Mexico.

In recent remarks to the press, President Donald Trump restated his intention to impose 25% tariffs on U.S. imports from Mexico and Canada as early as Feb. 1. His reasoning: "vast" illegal immigration and "massive" amounts of fentanyl coming to the U.

Reversing the trend will require police on the reservation, which has none, and closer detox and rehabilitation centers that cater to Native Americans, tribal members and advocates say.

"If I could save at least one person out there, and I may not even know who that person is, it's a blessing in memory of my son," said Terrie Mirabal.

I think he’s going to be wise in how he does that,’ the House speaker said Monday of Trump’s warnings to America’s neighbors.

President Donald Trump's nominee to run the Commerce Department, Howard Lutnick, said on Wednesday that Canada and Mexico can avoid looming U.S. tariffs if they act swiftly to close their borders to fentanyl,

President Claudia Sheinbaum is detaining more migrants, seizing more fentanyl and positioning her country as a key ally against China. But the U.S. stance has shifted, too.

The drug is increasingly manufactured in and trafficked from the U.S.’s northern neighbor, though the numbers remain small compared with Mexico.

Are dropping fentanyl-related death rates concealing other issues in the fight against this brutal form of addiction?

Secretary of Commerce-designate Howard Lutnick told a Senate committee that the threat of imposing a 25% tariff was to get Canada and Mexico to “respect” the United States and stop the flow of fentanyl into the country.

He noted those tariffs were separate from a broad effort by the Commerce Department, the U.S. Trade Representative’s office and the Treasury Department to review trade relations and tariffs by April 1.