aProximate TM is an advanced in vitro model of kidney proximal tubule cells (PTCs) that closely mimics physiological conditions. Derived from fresh human kidney tissue, aProximate TM PTCs are cultured ...

Science, founded by Thomas A. Edison in 1880 and published by AAAS, today ranks as the world's largest circulation general science journal. Published 51 times a year, Science is renowned for its ...

The USC Stem Cell laboratory of Andy McMahon has identified a type of injured cell that might contribute to the transition from an acute kidney injury to chronic kidney disease, as described in a new ...

Extract: This report concerns two patients with primary renal tubular acidosis (RTA) in whom the abnormality in hydrogen excretion was shown to result from inappropriate urinary loss of bicarbonate ...

Transverse tubules (T-tubules) play a significant role in muscle contraction. However, the underlying mechanism of their ...

The calcium-sensing receptor (CSR) is a G-protein receptor that plays a critical role in calcium regulation. In the kidney, the CSR regulates calcium reabsorption in the thick ascending limb, where ...

Renal cell carcinoma, also called hypernephroma, is a cancer of the kidneys that forms in the proximal convoluted tubule. In the UK, it is the eighth most common cancer among adults, affecting 9,300 ...

Every day our kidneys tackle the daunting task of continuously cleaning our blood to prevent waste, salt and excess fluid from building up inside our bodies. To achieve this, the kidneys’ ...