The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 11 on a 47-32 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Preview the San Francisco 49ers' NFL Week 11 matchup with the Cardinals, including live stream, TV channel, odds, and game information.

USA Today's NFL experts make their picks for a Week 11 showdown between the Buffalo Bills and Tampa Bay Buccaneers

Kickoff from State Farm Stadium is set for 4:25 p.m. ET on FOX. The 49ers are 3.5-point favorites, according to the latest 49ers vs. Cardinals odds. The over/under for total points scored is 48.5. Before making any 49ers vs. Cardinals picks, make sure you check out the NFL picks from the SportsLine Projection Model.

The Tampa Bay Buccaneers need to bounce back in a big way against a tough opponent in Week 11. After a loss to the best team in the AFC East, the New England Patriots, they now battle the team behind them in the standings,