Optimized interstitial migration of leukocytes is necessary for their timely arrival at sites of tissue injury and microbial assault. This process is regulated by a multitude of cell-intrinsic and ...

During immune surveillance and inflammation, leukocytes exit the vasculature through transient openings in the endothelium without causing plasma leakage. However, the exact mechanisms behind this ...

The basic route and mechanisms for leukocyte migration across the endothelium remain poorly defined. We provide definitive evidence for transcellular (i.e., through individual endothelial cells) ...

When a healthcare professional administers a drug through a venous cannula, there is a small risk of extravasation, which means the solution leaks out of the veins and into the surrounding tissue. If ...

When chemotherapy drugs accidentally leak into the tissues surrounding your veins or catheter, it’s called extravasation. While it doesn’t happen very often, it’s a serious complication. Chemotherapy ...