Motor neuron diseases, such as amyotrophic lateral sclerosis (ALS) and hereditary spastic paraplegia (HSP), share physical ...

Researchers showed that large motor neurons face high metabolic stress, making them more prone to degeneration. Reducing this ...

An international research team, led by Shinghua Ding at the University of Missouri, has identified a previously unknown ...

A University of Missouri-led discovery could pave the way for improved diagnosis and treatment of unexplained movement ...

An international research team led by Shinhua Ding, a professor at the University of Missouri College of Engineering, has ...

Currently no therapies can stop the spread of tau aggregates in the brains of patients with Alzheimer's disease. Our human neuron model of tau spread overcomes the limitations of previous models and ...

Weill Cornell Medicine scientists have developed an innovative human neuron model that robustly simulates the spread of tau protein aggregates in the brain—a process that drives cognitive decline in ...

Areflexic, or flaccid, bladder and bowels occur when the spinal cord injury is low enough to damage the cauda equina and alpha motor neurons. It also occurs in all spinal cord injury patients during ...