Protein phosphorylation — the selective addition of phosphate groups to proteins — is a regulatory mechanism that is fundamental to life. Conversely, dysregulated phosphorylation has been implicated ...

Enzymes known as kinases play a critical role in cell growth, metabolism and signaling in a multitude of organisms across the tree of life—from algae to helminths to mammals. Now, scientists have ...

An illustration shows the structure of an inhibitor bound to the active site of membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase. An inhibitor bound to the active site of ...

Your doctor may recommend the creatine phosphokinase (CPK) test if there's a need to measure CPK enzyme levels in your blood. The cells in your body require this creatine kinase enzyme to generate ...

Profiling kinase inhibitors is a critical step in the development of chemical probes or kinase drugs. The ability to generate an inhibitory profile of a compound across a broad collection of kinases ...

The results of research by scientists at Barts Cancer Institute at Queen Mary University of London has identified a sequential drug treatment approach that can reverse the resistance of leukemia cells ...