Current de novo gene construction 1,2,3,4 rests on 1990's technology for chemical oligonucleotide synthesis, which is costly and has error rates of 1 in 300 base ...
The prospect of generating synthetic genes and genomes has only been realized because of the availability of programmable building blocks in the form of synthetic oligonucleotides. However, the speed, ...
- The next frontier in oligonucleotide synthesis is the direct synthesis of gene-length sequences. - Ansa synthesized a 1005 base long oligonucleotide with industry-leading accuracy. - Ansa will be ...
Microarray synthesis of DNA oligonucleotides costs a fraction of a penny per base. But such methods can’t make pieces longer than about 200 bases. And stitching those oligonucleotide fragments into ...
The use of oligonucleotides as therapeutic agents is of great interest, particularly when it comes to siRNA and antisense oligonucleotides. However, the difficulty of targeting the right organ and ...
The gold standard for DNA writing, phosphoramidite chemistry, works incredibly well on short, uncomplicated, oligos. For longer stretches of DNA, which may contain DNA with complex features such as ...
REDWOOD CITY, Calif., May 14, 2024 (GLOBE NEWSWIRE) -- Codexis, Inc. (NASDAQ: CDXS), a leading enzyme engineering company, today announced it has successfully synthesized an oligonucleotide via an ...
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