We have investigated the unusual observation that depolarization of rat basophilic leukemia cells in high potassium not only fails to induce secretion, but also inhibits the secretion induced when ...

Voltage-gated calcium channels swing open with passing action potentials, allowing calcium ions into the cell, and slide shut when the membrane depolarization has passed. Two papers this month suggest ...

Figure 1: Reciprocal GABA-mediated synaptic input to RBCs is mediated by A17 amacrine cells. Figure 3: Neither membrane depolarization nor VGCC activation triggers GABA release from A17 cells. If GABA ...

Researchers report how a mutation in a gene involved in the regulation of calcium inside brain cells can help trigger blackouts of the brainstem, the center that controls heartbeat and breathing, and ...

IT has been postulated that calcium ions act as the link between depolarization and contraction in cardiac 1 and skeletal muscle 2. This hypothesis is based on the results of experiments relating the ...

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

Increases in the extracellular concentration of calcium ions above 1.8 millimoles per liter caused a reversible decrease in the sensitivity of the muscle postjunctional membrane to carbamylcholine. A ...

Transgenic tobacco leaves after 24 hours of green light exposure: a, plant with anion channel GtACR1; green light-induced membrane potential change (depolarization) is shown on the left. b, plant with ...

I am interested in how cells communicate and process information through the use of systems of interacting signaling molecules, especially ion channels, and transporters. Behind this interest is a ...

Joseph Priestley, one of the three scientists credited with the discovery of oxygen, described the death of mice that were deprived of oxygen. However, he was also well aware of the toxicity of too ...