Chloride channels and antiport mechanisms are pivotal for maintaining cellular ion homeostasis and regulating physiological processes such as muscle contraction, epithelial fluid transport and ...

Chloride channels, particularly those of the CLC family, are vital for cellular homeostasis by facilitating the exchange of chloride ions and protons across membranes. These transport proteins govern ...

Researchers have found that a primitive type of ion channel similar to those found in mammalian nerve cells helps bacteria resist the blast of acid they encounter in the stomach of their hosts. The ...

In the cells of the Arabidopsis plant, exposure to sodium chloride (NaCl) induces the movement (translocation) of the green fluorescent protein (GFP) tagged chloride channel, GFP-AtCLCf, from the ...

Scientists identified a previously unknown chloride ion channel, which they named alkaliphile (Alka), as a taste receptor for alkaline pH. The sense of taste is among the first to come into contact ...

Chloride ion flows that enter the cells play an important role in the duplication of glioblastoma cells, a highly aggressive brain tumor. This is the finding of research recently published in the ...

Credit: Shutterstock. NMD670 is a first-in-class small molecule inhibitor of the skeletal muscle specific chloride ion channel. The Food and Drug Administration (FDA) has granted Orphan Drug ...

Neuromuscular disease specialist NMD Pharma A/S has been given U.S. FDA approval for a phase IIb trial of NMD-670, after demonstrating proof of mechanism for the orally-available chloride ion ...

NMD Pharma Publishes Comprehensive Data Package for NMD670 in Science Translational Medicine ClC-1 is a chloride ion channel specifically expressed in skeletal muscle cells that normally dampens ...