What makes the elderly and people with underlying conditions more vulnerable to COVID-19? According to a new study, clues can be found in the proteins involved in initiating infection, as the virus ...

Cholesterol oxidation products, commonly termed oxysterols, have emerged as critical modulators in cellular physiology and pathology. These oxidised derivatives of cholesterol feature additional polar ...

The most prevalent human diseases in industrialized countries include obesity, type 2 diabetes, cancer, neurodegenerative, and cardiovascular diseases. A common feature of these ailments is ...

EPFL scientists have identified a molecular pathway that protects cells from lipid oxidation and ferroptosis, a regulated ...

Researchers report on a newly discovered biochemical pathway that protects cells from a type of cell death called ferroptosis. The hallmarks of cancer include rapid cell reproduction and metabolic ...

The hallmarks of cancer include rapid cell-reproduction and metabolic activity. But these processes also lead to increased cellular stress and oxidation, and the risk of cell death. To circumvent ...

Meenakshi Bhat, Yongyut Rojanasakul, Susan L. Weber, Jane Y. C. Ma, Vincent Castranova, Daniel E. Banks and Joseph K. H. Ma The mechanism of bleomycin-induced pulmonary fibrosis is not yet clear.

This investigation tested the hypothesis that depletion of intracellular glutathione, in contrast to its oxidation, could lead to non-native oxidation of protein thiols, thereby trapping proteins in ...