The NFL season continues in Week 11 when the San Francisco 49ers host the Arizona Cardinals on Sunday. Start time, how to watch, streaming and NFL schedule.

A big stretch of games begins for the San Francisco 49ers on Sunday in Arizona against the Cardinals. Here's how to watch their Week 11 showdown.

The San Francisco 49ers and Arizona Cardinals face off in Week 11 of the NFL today. Here's where to watch and start time

The San Francisco 49ers open the game with a 98-yard kick return and running back Christian McCaffrey caps off the drive on the first play with a 1-yard rushing touchdown on the road against the Arizona Cardinals in the first 13 seconds of the game.

With the defense and special teams coming up with big plays, the 49ers dominate Cardinals in Brock Purdy’s return.

Expert recap and game analysis of the San Francisco 49ers vs. Arizona Cardinals NFL game from November 16, 2025 on ESPN.

Arizona Cardinals vs San Francisco 49ers picks, predictions, odds, win probabilities for NFL Week 11 Sunday game on Nov. 16. Who will win game today?

Kickoff from State Farm Stadium is set for 4:25 p.m. ET on FOX. The 49ers are 3.5-point favorites, according to the latest 49ers vs. Cardinals odds. The over/under for total points scored is 48.5. Before making any 49ers vs. Cardinals picks, make sure you check out the NFL picks from the SportsLine Projection Model.

Charlotte native Owen McCown led the Roadrunners' offense with 306 yards, three total touchdowns, and an interception in his homecoming as head coach Jeff Traylor and his team improved to 5-5, needing one more win to achieve bowl eligibility.