Oct 6, 2024; Santa Clara, California, USA; San Francisco 49ers tight end George Kittle (85) gestures after a catch against the Arizona Cardinals during the fourth quarter at Levi's Stadium. Mandatory Credit: Darren Yamashita-Imagn Images / Darren Yamashita-Imagn Images

The San Francisco 49ers open the game with a 98-yard kick return and running back Christian McCaffrey caps off the drive on the first play with a 1-yard rushing touchdown on the road against the Arizona Cardinals in the first 13 seconds of the game.

Deommodore Lenoir is the only player on the San Francisco 49ers injury report vs. the Arizona Cardinals as he is questionable with a calf issue.

Charlotte native Owen McCown led the Roadrunners' offense with 306 yards, three total touchdowns, and an interception in his homecoming as head coach Jeff Traylor and his team improved to 5-5, needing one more win to achieve bowl eligibility.

Needing depth on the defense, San Francisco waived quarterback Adrian Martinez and added Clelin Ferrell to the 53-man roster from the practice squad. They also elevated cornerback Eli Apple from the practice squad, which could indicate that Deommodore Lenoir may not be able to go on Sunday after sustaining a calf injury during practice this week.

Charlotte 49ers prepare for a road game against the undefeated Virginia Tech, focusing on overcoming the Hokies' potent offense led by players like Hansberry and Avdalas.

The San Francisco 49ers and Arizona Cardinals are two NFL teams that have had rough luck dealing with an avalanche of injuries so far this season.