The Los Angeles Rams and San Francisco 49ers will meet on Sunday, and Sean McVay's team is calling up two players from the practice squad.

Running it heavily against the Rams with McCaffrey and Robinson is pivotal for the 49ers. Doing so will enhance the offense and their chances for victory. Follow Jose on X (Twitter) @JS3sanchez_to interact with him on the 49ers.

San Francisco tight end George Kittle explained why the 49ers' games against the Los Angeles Rams stand out to him ahead of their Week 10 matchup.

Let's take a look at some of the best anytime touchdown scorer picks for Rams vs. 49ers in Week 10, with odds from DraftKings Sportsbook. If you'd like a full game forecast for Rams vs. 49ers and more NFL player prop recommendations, head to SportsLine.

Kyle Shanahan and Sean McVay have faced off 18 times leading their respective teams, with Shanahan currently holding an 11–7 edge over McVay. But those head-to-head matchups only tell part of the story of the rivalry between these two sides. While both men first got their shot at a top NFL job in 2017, their history goes back further.

Los Angeles Rams defensive lineman Jared Verse shared a hilarious NSFW response about the historic rivalry with the San Francisco 49ers.

After a mildly embarrassing performance in Week 5, the Rams defense is eager for the rematch against QB Mac Jones and the 49ers in Week 10.

The San Francisco 49ers' defensive front is getting a much-needed boost ahead of their Week 10 matchup against the Los Angeles Rams. Defensive end Bryce Huff, who missed the last two games with a hamstring injury,